With Sens. Rand Paul and Thom Tillis opposed to the package, GOP leaders can afford only one more defection. And multiple Republicans aren't yet sold on the measure.

Republican Sen. Thom Tillis of North Carolina said Sunday he will not seek reelection next year, an abrupt announcement that came one day after he staked out his opposition to President Donald Trump’s tax breaks and spending cuts package because of its reductions to health care programs.

As many of my colleagues have noticed over the last year, and at times even joked about, I haven't exactly been excited about running for another term,” Thom Tillis said. | Francis Chung/POLITICO Sen.