Notably, all immunoglobulins are glycosylated to varying degrees and glycosylation is an important posttranslational modification that affects many properties of proteins including folding, stability, ...

Glycosylation is a common post-translational modification event in the secretory pathway of most eukaryotic expression systems; however, it is known to be species-, tissue- and cell type-specific ...

To date, dupilumab has been studied across more than 60 clinical studies involving more than 10,000 patients with various chronic diseases driven in part by type 2 inflammation.

To date, dupilumab has been studied across more than 60 clinical trials involving more than 10,000 patients with various chronic diseases driven in part by type 2 inflammation.

Approval based on pivotal results showing improvements in sustained disease remission and reductions in itch and oral corticosteroid use compared to placebo in adults with BP BP is a chronic ...

Approval based on pivotal results showing improvements in sustained disease remission and reductions in itch and oral corticosteroid use compared to placebo in adults with BP BP is a chronic, ...

Early trials found that both garadacimab and sebetralstat were safe when used in patients living with hereditary angioedema, which speaks to the promise of the FDA-approved garadacimab. Timothy ...

The association between dupilumab and psoriasis was further supported by validation in patients with asthma without atopic dermatitis (HR 2.13, 95% CI 1.38-3.31), the authors noted.

Patients with atopic dermatitis (AD) treated with dupilumab may face a slightly elevated risk of developing psoriasis, with new study data showing a cumulative 3-year incidence of 2.86% compared ...

Between baseline and week 12, researchers additionally found a comparable level of improvement in prebronchodilator FEV 1 with dupilumab vs. placebo when split into those with emphysema (least ...

Differential glycosylation plays a key role in modulating glycoprotein functions by influencing protein interactions. In this study, we employed the GAP–MS platform to characterize glycan-dependent ...

Sanofi and Regeneron Pharmaceuticals, Inc. presented positive results from the EVEREST phase 4 study of adults with severe chronic rhinosinusitis with nasal polyps (CRSwNP) and coexisting asthma. In ...