Cooper Flagg's injury is one of the biggest storylines entering the NCAA Tournament. Here's the latest surrounding the Duke star's injury and what FOX Sports analysts believe of the Blue Devils' title chances.

Several contenders in the men’s and women’s NCAA basketball tournaments are dealing with significant injuries.

For a few minutes, it looked like the Tar Heels were going to validate their critics. They committed turnovers on four of their first six possessions against a San Diego State defense ranked 13th in the country on KenPom. UNC's offense should have been good enough to hang with that unit, but it was a bad beginning.

Michigan was given a No. 5 seed, mainly because of a NET ranking of No. 23. The Wolverines had an eye-popping 12 Q1 victories this season, including 2 victories over No. 3 seed Wisconsin and wins over NCAA Tournament teams Maryland, Oregon, Purdue, UCLA and Xavier among others.

The First Four has been around since 2011 and features the last four automatic qualifiers and last four at-large bids playing to whittle the field from 68 to 64. This year will see two 16-seed vs. 16-seed matchups and two 11-seed vs. 11-seed matchups, but don’t write these games off because they involve double-digit seeds.