The top-seeded Cougars were in enemy territory at Midwest Region games in Indianapolis, but they dominated Tennessee in Sunday’s region final to reach the Final Four.

It’s the Duke Blue Devils vs Houston in the Final Four of the March Madness bracket. Here’s our prediction, pick for the 2025 NCAA Tournament game.

It's been 17 years since this scenario played out in March Madness, following wins by Duke, Auburn, Houston and Florida.