On Monday, Texans coach DeMeco Ryans said Mixon is still working his way back from the ankle injury and that a timetable for his return remains up in the air. Most notably, Ryans changed his wording from “day to day” to “week to week” when describing the timeline of Mixon’s status.

Having Mixon back would have benefitted the Texans against one of the league’s worst run defenses. Buffalo enters NRG Stadium allowing a league-leading 5.7 yards per run. In Sunday’s loss to the Baltimore Ravens, the Bills allowed 271 rushing yards and 8.0 yards per run, 199 of which came from Derrick Henry.