Newsweek's guide to how to bet Chiefs vs. 49ers breaks down Sunday afternoon's must-see battle between the reigning champs and Kyle Shanahan's Niners.

The Ravens decisive Week 7 win solidified their spot as the second-favorite to win the Super Bowl. But dark horse contenders lurk.

The Chiefs, like the 49ers with Christian McCaffrey, have been missing their own starting running back all season. Isiah Pacheco had leg surgery in mid-September and could return six-to-eight weeks after that procedure. Kansas City is also missing wide receivers Hollywood Brown and Rashee Rice, the latter of whom had knee surgery last week.